The present study describes the case of a 63-year-old woman presenting with headache, dizziness and vomiting due to a an ovoid mass in the left pre-bulbar cistern, apparently arising from the lower clivus and the foramen magnum. The clinical history revealed the subtotal removal of a right cerebellar low-grade glioma 15 years previously and subsequent conventional 60-Gy radiotherapy. Notably, following gross total resection, histopathological examination showed microscopic features that resulted in a diagnosis of anaplastic ependymoma. The patient underwent surgery to remove the mass and post-operative chemotherapy with temozolomide. A progressive improvement of neurological signs and symptoms was observed during the postoperative course. At the 6-month follow-up, the patient was free from clinical and radiological recurrence. The unusual features of this rare secondary brain tumor were the extrassial location in the posterior fossa, the unusual age-associated location of the histological subtype and the fact that it closely mimicked a skull-base meningioma.

Radiation-induced anaplastic ependymoma mimicking a skull base meningioma: A case report / Spallone, A.; Marchione, P.; Di Capua, M.; Belvisi, D.. - In: EXPERIMENTAL AND THERAPEUTIC MEDICINE. - ISSN 1792-0981. - 11:2(2016), pp. 455-457. [10.3892/etm.2015.2945]

Radiation-induced anaplastic ependymoma mimicking a skull base meningioma: A case report

Di Capua M.;Belvisi D.
2016

Abstract

The present study describes the case of a 63-year-old woman presenting with headache, dizziness and vomiting due to a an ovoid mass in the left pre-bulbar cistern, apparently arising from the lower clivus and the foramen magnum. The clinical history revealed the subtotal removal of a right cerebellar low-grade glioma 15 years previously and subsequent conventional 60-Gy radiotherapy. Notably, following gross total resection, histopathological examination showed microscopic features that resulted in a diagnosis of anaplastic ependymoma. The patient underwent surgery to remove the mass and post-operative chemotherapy with temozolomide. A progressive improvement of neurological signs and symptoms was observed during the postoperative course. At the 6-month follow-up, the patient was free from clinical and radiological recurrence. The unusual features of this rare secondary brain tumor were the extrassial location in the posterior fossa, the unusual age-associated location of the histological subtype and the fact that it closely mimicked a skull-base meningioma.
2016
Post irradiation tumors; Radiation-induced ependymoma; Radiation-induced meningioma; Skull base approach
01 Pubblicazione su rivista::01i Case report
Radiation-induced anaplastic ependymoma mimicking a skull base meningioma: A case report / Spallone, A.; Marchione, P.; Di Capua, M.; Belvisi, D.. - In: EXPERIMENTAL AND THERAPEUTIC MEDICINE. - ISSN 1792-0981. - 11:2(2016), pp. 455-457. [10.3892/etm.2015.2945]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1388943
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